Laccase-mediated oxidation of the steroid hormone 17?-estradiol 1 in organic solvents or in a biphasic system allowed the isolation of the C-C and C-O dimers 1a-d. Concerning the C-C dimers, the relative ratio of the symmetric 4-4? 1c and asymmetric 4-2? 1d products was influenced by the catalyst used. Both 1c and 1d were formed as an equimolar mixture of diastereomeric atropisomers.
Laccase-mediated oxidation of the steroid hormone 17beta-estradiol in organic solvents
Ottolina G;Riva S;
2004
Abstract
Laccase-mediated oxidation of the steroid hormone 17?-estradiol 1 in organic solvents or in a biphasic system allowed the isolation of the C-C and C-O dimers 1a-d. Concerning the C-C dimers, the relative ratio of the symmetric 4-4? 1c and asymmetric 4-2? 1d products was influenced by the catalyst used. Both 1c and 1d were formed as an equimolar mixture of diastereomeric atropisomers.File in questo prodotto:
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