The bioisosterism of the trifluoromethyl group, namely its capacity to act as a replacement for groups with similar size or shape without substantially altering key biological properties such as binding affinity, remains a controversial issue.
Assessing the bioisosterism of the trifluoromethyl group with a protease probe
Zanda M
2009
Abstract
The bioisosterism of the trifluoromethyl group, namely its capacity to act as a replacement for groups with similar size or shape without substantially altering key biological properties such as binding affinity, remains a controversial issue.File in questo prodotto:
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