Study on a possible effect of four longevity candidate genes (ACE, PON1, PPAR-gamma and APOE) on human fertility

The present study investigated for a possible effect on fertility of four longevity candidate genes (ACE, PON1, PPAR-c, APOE) in order to determine whether they have a pleiotropic action at different life ages. The study population was 151 healthy unrelated subjects. Only PPAR-c and APOE showed an effect on fertility. The PPAR-c Pro/Ala genotype, which had showed an association with longevity only in men, was found associated only in men with having produced more children (6.1 ± 3.3) than the Pro/Pro genotype (3.3 ± 1.9; P = 0.001). APOE*2 allele, which has been consistently associated with longevity, was confirmed to be associated with the lowest fertility (P = 0.03). The logistic regression analysis indicated that APOE and PPAR-c polymorphisms may be considered independent determinants of reproductive efficiency. These data suggest that the APOE*2 allele follows the model of antagonist pleiotropy, while the PPAR-c Pro/Ala genotype seems to exert beneficial effects both early in life and in advanced age in a gender-specific way.