The self-assembly in the crystal state of the terminally protected, linear dipeptide Boc-(S,S)c(3)diPhe-(R,R)c(3)diPhe-NHiPr (1) through intermolecular hydrogen bonds leads to the formation of a supramolecular helix of large diameter (18 angstrom), internally decorated with phenyl rings. As a result, a hollow helical channel large enough to accommodate guest molecules is observed. This supramolecular structure differs from previous examples of peptide nanotubes. Compound 1 incorporates a highly restricted cyclopropane phenylalanine analogue ( c(3)diPhe) with remarkable conformational properties.
A helical, aromatic, peptide nanotube
Marco Crisma;Claudio Toniolo;
2006
Abstract
The self-assembly in the crystal state of the terminally protected, linear dipeptide Boc-(S,S)c(3)diPhe-(R,R)c(3)diPhe-NHiPr (1) through intermolecular hydrogen bonds leads to the formation of a supramolecular helix of large diameter (18 angstrom), internally decorated with phenyl rings. As a result, a hollow helical channel large enough to accommodate guest molecules is observed. This supramolecular structure differs from previous examples of peptide nanotubes. Compound 1 incorporates a highly restricted cyclopropane phenylalanine analogue ( c(3)diPhe) with remarkable conformational properties.File in questo prodotto:
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