2-aminoalkanesulfonic acids were synthesized by a three-component alkene-SO3.DMF-acetonitrile reaction, followed by acetamido hydrolysis. Trifluoromethanesulfonic acid was added to the amino-sulfonation mixture to accelerate the reaction and prevent the competitive formation of by-products. The reported two step procedure provided a concise and versatile approach to new analogues of the natural amino acid taurine.
Amino sulfonation of alkenes in a three-component reaction
Machetti Fabrizio;
2002
Abstract
2-aminoalkanesulfonic acids were synthesized by a three-component alkene-SO3.DMF-acetonitrile reaction, followed by acetamido hydrolysis. Trifluoromethanesulfonic acid was added to the amino-sulfonation mixture to accelerate the reaction and prevent the competitive formation of by-products. The reported two step procedure provided a concise and versatile approach to new analogues of the natural amino acid taurine.File in questo prodotto:
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