Thelithium-bromine exchange of bicyclic bromo-substituted gamma- and delta-lactams has been investigated finding that the lithium intermediates undergo a ring-enlargement reaction eventually leading to the isomeric six- and seven-membered lactams. Interception of the lithium species with electrophiles allows the synthesis of a series of functionalized quinolinones and benzoazepines
A New Carbanionic One Carbon Ring Enlargement-Alkylation of Lactams
Mordini Alessandro;Reginato Gianna
2003
Abstract
Thelithium-bromine exchange of bicyclic bromo-substituted gamma- and delta-lactams has been investigated finding that the lithium intermediates undergo a ring-enlargement reaction eventually leading to the isomeric six- and seven-membered lactams. Interception of the lithium species with electrophiles allows the synthesis of a series of functionalized quinolinones and benzoazepinesFile in questo prodotto:
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