Two new diastereomeric ferrocenyl triphosphine ligands P3Chir 1 and 2 have been conveniently synthesized through a multistep reaction sequence starting from (R)-(S)-diphenylphosphinoferrocenylamine [(R)-(S)-PPFA]. Chromatographic resolution of the diborane protected-phosphine oxide derivatives, followed by a stereoconservative reduction/deboronation step, gave the pure triphosphines P3Chir in which the planar chirality of the ferrocenyl unit is combined with phosphorus and carbon stereocenters in an unprecedented molecular assembly.
Synthetic Approaches to New Diasteromerically Pure Ferrocenyl Triphosphines Comibining Phosphorus, Planar and Carbon Chirality
Pierluigi Barbaro;Claudio Bianchini;Giuliano Giambastiani;Dante Masi;
2004
Abstract
Two new diastereomeric ferrocenyl triphosphine ligands P3Chir 1 and 2 have been conveniently synthesized through a multistep reaction sequence starting from (R)-(S)-diphenylphosphinoferrocenylamine [(R)-(S)-PPFA]. Chromatographic resolution of the diborane protected-phosphine oxide derivatives, followed by a stereoconservative reduction/deboronation step, gave the pure triphosphines P3Chir in which the planar chirality of the ferrocenyl unit is combined with phosphorus and carbon stereocenters in an unprecedented molecular assembly.File in questo prodotto:
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