Several cyclic oligodeoxynucleotides with different base composition and size have been prepared from 5?,3?-unprotected linear precursors, using a bifunctional phosphorylating reagent. The final deprotected ollgomers have been characterized by 1H- and 31P-NMR. The present procedure is particularly useful for millimolar scale syntheses.
One pot solution synthesis of cyclic oligodeoxyribonucleotides
Capobianco;
1990
Abstract
Several cyclic oligodeoxynucleotides with different base composition and size have been prepared from 5?,3?-unprotected linear precursors, using a bifunctional phosphorylating reagent. The final deprotected ollgomers have been characterized by 1H- and 31P-NMR. The present procedure is particularly useful for millimolar scale syntheses.File in questo prodotto:
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