Abstract: The role of C-type natriuretic peptide (CNP) in the pathophysiology of chronic heart failure (CHF) has not been yet fully clarified. In the present study we measured plasma levels of CNP in 64 controls and in 133 patients with CHF by a radioimmunoassay after a preliminary solid-phase extraction on Sep-Pak C18. We also studied myocardial CNP production (difference in levels between the arterial and coronary sinus (CS) blood) in 6 patients. CNP levels in controls were 2.5 +/- 0.1 pg/ml and resulted significantly increased in patients with CHF as a function of clinical severity. A significant relation was also found between CNP plasma levels and left ventricular ejection fraction (EF). Significantly higher CNP levels were found in the CS than in arterial blood. These data suggest a role for this peptide, as autocrine and/or endocrine mediator.
C-type natriuretic peptide plasma levels and chronic heart failure
2005
Abstract
Abstract: The role of C-type natriuretic peptide (CNP) in the pathophysiology of chronic heart failure (CHF) has not been yet fully clarified. In the present study we measured plasma levels of CNP in 64 controls and in 133 patients with CHF by a radioimmunoassay after a preliminary solid-phase extraction on Sep-Pak C18. We also studied myocardial CNP production (difference in levels between the arterial and coronary sinus (CS) blood) in 6 patients. CNP levels in controls were 2.5 +/- 0.1 pg/ml and resulted significantly increased in patients with CHF as a function of clinical severity. A significant relation was also found between CNP plasma levels and left ventricular ejection fraction (EF). Significantly higher CNP levels were found in the CS than in arterial blood. These data suggest a role for this peptide, as autocrine and/or endocrine mediator.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
