High-energy radiation processing, a smart approach to obtain PVP-graft-AA nanogels.

Poly(N-vinylpyrrolidone)-grafted-acrylic acid biocompatible nanogels(NGs) were prepared using exiting industrial-type electron accelerator and setups, starting from semi-dilute aqueous solutions of a commercial PVP and the acrylic acid monomer. As a result, NGs with tunable size and structure can be obtained quantitatively. Sterility was also impartedat the integrated doseabsorbed. The chemical structure of the NGs produced was confirmed throughFourier Transformer Infrared Spectroscopy (FT-IR). The molecular and physico-chemical properties of NGs, such as the hydrodynamic dimensionsand surface charge densities, at the variance of polymer and monomer concentrations in the irradiated solutions,are here discussed