Chiral delta-hydroxy-beta-ketoesters are easily available through the enantioselective vinylogous aldol reaction of Chan's diene promoted by a SiCl4/chiral phosphoramide catalytic system. The procedure is conveniently exploited for a very rapid approach to (+)-kavain, a natural bio-active alpha-pyrone compound.
A new procedure for the enantioselective vinylogous aldol reaction of Chan's diene
Rosaria Villano;
2006
Abstract
Chiral delta-hydroxy-beta-ketoesters are easily available through the enantioselective vinylogous aldol reaction of Chan's diene promoted by a SiCl4/chiral phosphoramide catalytic system. The procedure is conveniently exploited for a very rapid approach to (+)-kavain, a natural bio-active alpha-pyrone compound.File in questo prodotto:
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