SiCl4 is an efficient and selective catalyst for the vinylogous Mannich reaction of linear and cyclic synthetic equivalents of acetoacetate dianion, leading to delta-amino-beta-ketoesters in moderate to high yields and complete gamma-selectivity; anti-diastereoselectivity was observed by using a gamma-methyl-substituted cyclic silyloxydiene.
A convenient approach to delta-amino-beta-ketoesters by vinylogous Mannich reaction of masked acetoacetates
Rosaria Villano;
2007
Abstract
SiCl4 is an efficient and selective catalyst for the vinylogous Mannich reaction of linear and cyclic synthetic equivalents of acetoacetate dianion, leading to delta-amino-beta-ketoesters in moderate to high yields and complete gamma-selectivity; anti-diastereoselectivity was observed by using a gamma-methyl-substituted cyclic silyloxydiene.File in questo prodotto:
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