Direct aromatic functionalization based on the use of a palladium catalyst and norbornene is a useful method to achieve straightforward synthesis of carbo- and heterocyclic compounds. New ring formation occurs through a cascade process triggered by ortho C-H alkylation (inter- and intramolecular) or arylation (homo- and heterocoupling) of aryl iodides. Up to four new carbon-carbon bonds are generated under palladium control in a single operation.
Palladium-Catalyzed Synthesis of Carbo- and Heterocycles through Norbornene-Mediated ortho C-H Functionalization
R Ferraccioli
2013
Abstract
Direct aromatic functionalization based on the use of a palladium catalyst and norbornene is a useful method to achieve straightforward synthesis of carbo- and heterocyclic compounds. New ring formation occurs through a cascade process triggered by ortho C-H alkylation (inter- and intramolecular) or arylation (homo- and heterocoupling) of aryl iodides. Up to four new carbon-carbon bonds are generated under palladium control in a single operation.File in questo prodotto:
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Descrizione: Palladium-Catalyzed Synthesis of Carbo- and Heterocycles through Norbornene-Mediated ortho C-H Functionalization
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