The chapter, by reviewing the papers appeared in the literature in the last 10 years, illustrates the different strategies used for the development of de novo-designed protein cages housing mononuclear and dinuclear metal-binding sites, as well as hemes and metalloporphyrins. We mainly focus on ?-helical coiled-coil and bundle structures, which self- assemble with the metal cofactors. Fewer examples of artificial metalloproteins based on ?-sheet structures have appeared in the literature and they are also described here.
De Novo Design of Protein Cages to Accommodate Metal Cofactors
Ornella Maglio;
2013
Abstract
The chapter, by reviewing the papers appeared in the literature in the last 10 years, illustrates the different strategies used for the development of de novo-designed protein cages housing mononuclear and dinuclear metal-binding sites, as well as hemes and metalloporphyrins. We mainly focus on ?-helical coiled-coil and bundle structures, which self- assemble with the metal cofactors. Fewer examples of artificial metalloproteins based on ?-sheet structures have appeared in the literature and they are also described here.File in questo prodotto:
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