The best of both: SIRT1/2 inhibitors were developed by combining chemical features of selisistat (SIRT1-selective inhibitor; blue) and carprofen (anti-inflammatory drug; red). The most potent compound (shown) increased acetyl-p53 and acetyl-?-tubulin levels, and induced slight apoptosis at 50 ?M in U937 cells, differently from selisistat and carprofen.
Carprofen analogues as sirtuin inhibitors: enzyme and cellular studies.
Altucci L;
2012
Abstract
The best of both: SIRT1/2 inhibitors were developed by combining chemical features of selisistat (SIRT1-selective inhibitor; blue) and carprofen (anti-inflammatory drug; red). The most potent compound (shown) increased acetyl-p53 and acetyl-?-tubulin levels, and induced slight apoptosis at 50 ?M in U937 cells, differently from selisistat and carprofen.File in questo prodotto:
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