The sestertepene (-)-wistarin has been isolated from a Red Sea sponge of the genus Ircinia. This metabolite is the enantiomer of (+)-wistarin, a tetracyclic metabolite previously isolated from the sponge Ircinia wistarii. The enantiomeric relationship was proved by comparison of the CD spectrum of (-)-wistarin with that of a synthetic sample of the (+)-isomer. A hypothetical biosynthesis of (-)-wistarin is discussed starting from a putative linear precursor.
(-)-Wistarin from the marine sponge Ircinia sp.: the first case of enantiomeric sesterterpenes
Fontana A;Mollo E;Cimino G
1999
Abstract
The sestertepene (-)-wistarin has been isolated from a Red Sea sponge of the genus Ircinia. This metabolite is the enantiomer of (+)-wistarin, a tetracyclic metabolite previously isolated from the sponge Ircinia wistarii. The enantiomeric relationship was proved by comparison of the CD spectrum of (-)-wistarin with that of a synthetic sample of the (+)-isomer. A hypothetical biosynthesis of (-)-wistarin is discussed starting from a putative linear precursor.File in questo prodotto:
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