A series of homoscalarane and scalarane compounds (2-7) have been isolated from two distinct species of Pacific Glossodoris nudibranchs. The structure and elucidation of the relative stereochemistry of the new metabolites 2 and 3 were obtained by spectroscopic methods. Compound 2 was ichthyotoxic at 0.1 ppm against Gambusia affinis and showed moderate activity (IC50 18 mu M) to inhibit mammalian phospholipase A2.
Scalarane and homoscalarane compounds from the nudibranchs Glossodoris sedna and Glossodoris dalli: Chemical and biological properties
Fontana A;Mollo E;Cimino G
2000
Abstract
A series of homoscalarane and scalarane compounds (2-7) have been isolated from two distinct species of Pacific Glossodoris nudibranchs. The structure and elucidation of the relative stereochemistry of the new metabolites 2 and 3 were obtained by spectroscopic methods. Compound 2 was ichthyotoxic at 0.1 ppm against Gambusia affinis and showed moderate activity (IC50 18 mu M) to inhibit mammalian phospholipase A2.File in questo prodotto:
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