Desymmetrization of meso-hydrobenzoin by irreversible acyl transfer using vinyl acetate as the acyl donor in the presence of Rhizopusjavanicus lipase or Candida cylindracea lipase enables the preparation of (R)-1-acetoxy-(S)-2-hydroxy-1,2-diphenylethane and (S)-1-acetoxy-(R)-2-hydroxy-1,2-diphenylethane respectively in excellent optical purity.
Desymmetrization of meso-hydrobenzoin via stereoselective enzymatic esterification
Nicolosi;Giovanni;Patti;Angela;Sanfilippo;Claudia
1994
Abstract
Desymmetrization of meso-hydrobenzoin by irreversible acyl transfer using vinyl acetate as the acyl donor in the presence of Rhizopusjavanicus lipase or Candida cylindracea lipase enables the preparation of (R)-1-acetoxy-(S)-2-hydroxy-1,2-diphenylethane and (S)-1-acetoxy-(R)-2-hydroxy-1,2-diphenylethane respectively in excellent optical purity.File in questo prodotto:
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