The optimisation of the kinetic resolution of 1,2-dihydroxy-3-ferrocenylpropane, (±)-1, by lipase-catalysed transesterification reactions is discussed. Enantiomerically pure forms of 1 gave access to the corresponding epoxide 8 that had been used as a homochiral starting material for the preparation of several difunctionalised ferrocenes bearing a stereocentre at the ?-position of the ferrocene backbone.
Chemoenzymatic approach to novel chiral difunctionalised ferrocenes
Angela Patti;Giovanni Nicolosi
2000
Abstract
The optimisation of the kinetic resolution of 1,2-dihydroxy-3-ferrocenylpropane, (±)-1, by lipase-catalysed transesterification reactions is discussed. Enantiomerically pure forms of 1 gave access to the corresponding epoxide 8 that had been used as a homochiral starting material for the preparation of several difunctionalised ferrocenes bearing a stereocentre at the ?-position of the ferrocene backbone.File in questo prodotto:
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