R)-(+)-Ferrocene cyanohydrin acetate, obtained by enzymatic acylation of ferrocene cyanohydrin, may be transformed by reduction and alkylation into novel ferrocenyl ?-aminoalcohoIs. Substitution of acetate by methanolic HNMe2 proceeds with racemisation, but significant diastereoselection is observed on Strecker reaction using (-)PhCH(Me)NHMe
Lipase catalysed resolution of ferrocene cyanohydrin: Access to novel ferrocenyl aminoalcohoIs and diamines
Giovanni Nicolosi;Angela Patti;
1997
Abstract
R)-(+)-Ferrocene cyanohydrin acetate, obtained by enzymatic acylation of ferrocene cyanohydrin, may be transformed by reduction and alkylation into novel ferrocenyl ?-aminoalcohoIs. Substitution of acetate by methanolic HNMe2 proceeds with racemisation, but significant diastereoselection is observed on Strecker reaction using (-)PhCH(Me)NHMeFile in questo prodotto:
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