A circular permutant (CP) is a protein variant characterized by the linking of the two chain ends and cleavage at another site. As a result, CPs have a different position of the N- and C-termini and present a different topology with respect to one another. Both the three-dimensional structure and the function of CPs are generally conserved. The two main genetic mechanisms that have been proposed to originate CPs are fusion/fission and permutation by duplication. Engineering of artificial CPs is increasingly exploited for biotechnological applications and research purposes.
Circularly Permuted Proteins
Morea V
2013
Abstract
A circular permutant (CP) is a protein variant characterized by the linking of the two chain ends and cleavage at another site. As a result, CPs have a different position of the N- and C-termini and present a different topology with respect to one another. Both the three-dimensional structure and the function of CPs are generally conserved. The two main genetic mechanisms that have been proposed to originate CPs are fusion/fission and permutation by duplication. Engineering of artificial CPs is increasingly exploited for biotechnological applications and research purposes.File in questo prodotto:
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