Two partial esters of conduritol E, namely (2R)-hydroxy-(1R,3R,4R)-triacetoxycyclohex-5-ene and (1S,2S)-dihydroxy-(3S,4S)-diacetoxycyclohex-5-ene, have been prepared in high chemical and optical yields from 'benzene cis-glycol' diacetate via OsO4 catalysed dihydroxylation followed by enantioselective esterification of the resulting conduritol E diacetate in the presence of Mucor miehei lipase.
Chemoenzymatic preparation of enantiopure partial esters of conduritol E
Sanfilippo;Claudia;Patti;Angela;Nicolosi;Giovanni
1997
Abstract
Two partial esters of conduritol E, namely (2R)-hydroxy-(1R,3R,4R)-triacetoxycyclohex-5-ene and (1S,2S)-dihydroxy-(3S,4S)-diacetoxycyclohex-5-ene, have been prepared in high chemical and optical yields from 'benzene cis-glycol' diacetate via OsO4 catalysed dihydroxylation followed by enantioselective esterification of the resulting conduritol E diacetate in the presence of Mucor miehei lipase.File in questo prodotto:
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