4-Tributylstannyl-5-substituted-pyrrolin-2-ones are prepared through the addition of tributylstannyl cyano cuprate to enantiomerically enriched N-protected ?-amino acetylenic esters. The regio- and stereoselectivity of the addition is discussed as a function of the substrates and of the reaction conditions. Cyclization of the (E)-isomers to the corresponding 4-stannylated pyrrolin-2-ones is reported
Stannylcuprationof chiral gamma-amino acetylenic esters: stereocontrolled synthesis of 3-tributylstannyl gamma-amino (E)-alkenoates as precursors of 4-stannylated pyrrolinones
Reginato Gianna;Mordini Alessandro;
1998
Abstract
4-Tributylstannyl-5-substituted-pyrrolin-2-ones are prepared through the addition of tributylstannyl cyano cuprate to enantiomerically enriched N-protected ?-amino acetylenic esters. The regio- and stereoselectivity of the addition is discussed as a function of the substrates and of the reaction conditions. Cyclization of the (E)-isomers to the corresponding 4-stannylated pyrrolin-2-ones is reportedFile in questo prodotto:
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