Interferons (IFN) are cytokines that upon binding to specific membrane receptors can modulate many biological activities, such as antiviral, immuno-modulatory and growth regulatory. They can specifically induce the expression of several endogenous proteins designated as IFN-induced proteins. Among the proteins positively regulated by type I (? and ?) and type II (?) IFNs, there is the murine Ifi200 family and its human counterpart HIN200, both localised on chromosome 1. Recent studies demonstrated that these proteins are involved in cell cycle regulation and differentiation both in vitro and in vivo. Here, we report on their principal properties, showing the genomic organization of both the murine and human loci.
Biological properties and genomic organization of the family of Interferon-inducible murine Ifi 200 and its human counterpart HIN200
NORIS E;
2003
Abstract
Interferons (IFN) are cytokines that upon binding to specific membrane receptors can modulate many biological activities, such as antiviral, immuno-modulatory and growth regulatory. They can specifically induce the expression of several endogenous proteins designated as IFN-induced proteins. Among the proteins positively regulated by type I (? and ?) and type II (?) IFNs, there is the murine Ifi200 family and its human counterpart HIN200, both localised on chromosome 1. Recent studies demonstrated that these proteins are involved in cell cycle regulation and differentiation both in vitro and in vivo. Here, we report on their principal properties, showing the genomic organization of both the murine and human loci.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
