6-Trifluoromethyl-12-aryl(vinyl)indolo[1,2-c]quinazolines are prepared in high yield through the palladium-catalyzed reaction of readily available bis(o-trifluoroacetamidophenyl)acetylene with aryl or vinyl halides and triflates. followed by cyclization of the resultant derivatives. The reaction, which tolerates a variety of important functional groups. probably involves the formation of a 3-aryl-2-(o-trifluoroacetamidophenyl)indole intermediate, followed by its cyclization to the indolequinazoline product. Formation of the indoloquinazoline nucleus has been unambiguously determined via X-ray analysis.
Indole[1,2-c]quinazolines by palladium-catalyzed cyclization of bis(o-trifluoroacetamidophenyl) acetylene with aryl and vinyl halides or triflates
Cassetta A;
2001
Abstract
6-Trifluoromethyl-12-aryl(vinyl)indolo[1,2-c]quinazolines are prepared in high yield through the palladium-catalyzed reaction of readily available bis(o-trifluoroacetamidophenyl)acetylene with aryl or vinyl halides and triflates. followed by cyclization of the resultant derivatives. The reaction, which tolerates a variety of important functional groups. probably involves the formation of a 3-aryl-2-(o-trifluoroacetamidophenyl)indole intermediate, followed by its cyclization to the indolequinazoline product. Formation of the indoloquinazoline nucleus has been unambiguously determined via X-ray analysis.File in questo prodotto:
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