The present invention relates to conformationally constrained homo- and heterodimeric mimetics of Smac with function as inhibitors of Inhibitor of Apoptosis Proteins (IAPs), the invention also relates to the use of these compounds in therapy, wherein the induction of apoptotic cell death is beneficial, especially in the treatment of cancer, alone or in combination with other active ingredients.
New homo- and heterodimeric smac mimetic compounds as apoptosis inducers
Federica COSSU;Carmelo Drago;Eloise Mastrangelo;Mario Milani De Mayo De Mari;
2013
Abstract
The present invention relates to conformationally constrained homo- and heterodimeric mimetics of Smac with function as inhibitors of Inhibitor of Apoptosis Proteins (IAPs), the invention also relates to the use of these compounds in therapy, wherein the induction of apoptotic cell death is beneficial, especially in the treatment of cancer, alone or in combination with other active ingredients.File in questo prodotto:
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8) Brevetto WO2013124701.pdf
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