Controlled dealkylation of dialkyl aryl ethers by substoichiometric BBr3 has been developed as a general tool for the differentiation of the oxygen functions in hydroquinone derivatives. The reaction proceeds smoothly at rt either on linear or branched alkyl ethers and provides the corresponding p alkoxy phenols RO Ar OH in high yields. With respect to the conventional alkylation path of Ar(OH)2, this process represents a tunable and convenient route to key intermediates for conjugated materials with differentiated side chains.
Controlled dealkylation by BBr3: efficient synthesis of para-alkoxy-phenols
M Bassetti
2012
Abstract
Controlled dealkylation of dialkyl aryl ethers by substoichiometric BBr3 has been developed as a general tool for the differentiation of the oxygen functions in hydroquinone derivatives. The reaction proceeds smoothly at rt either on linear or branched alkyl ethers and provides the corresponding p alkoxy phenols RO Ar OH in high yields. With respect to the conventional alkylation path of Ar(OH)2, this process represents a tunable and convenient route to key intermediates for conjugated materials with differentiated side chains.File in questo prodotto:
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