Non-racemic Boc-protected -stannylated--(aminoalkyl)acrylates of (Z) geometry have been selectively obtained by addition of stannylcuprate onto propargylamines, followed by reaction with carbon dioxide. Stille coupling has been investigated and a small library of six new -branched--(aminoalkyl)acrylates obtained. These compounds are useful intermediates for the synthesis of new enantiomerically enriched -amino acids.
Synthesis of non racemic B-branced a-(aminoalkyl)-acrylates from naturally occurring amino acids
Reginato Gianna;Mordini Alessandro;
2002
Abstract
Non-racemic Boc-protected -stannylated--(aminoalkyl)acrylates of (Z) geometry have been selectively obtained by addition of stannylcuprate onto propargylamines, followed by reaction with carbon dioxide. Stille coupling has been investigated and a small library of six new -branched--(aminoalkyl)acrylates obtained. These compounds are useful intermediates for the synthesis of new enantiomerically enriched -amino acids.File in questo prodotto:
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