In an attempt to replace harmful or carcinogenic solvents (such as dichloromethane, acetone, etc.) with non-harmful and greener ones, the possibility of performing four already developed ring-opening methodologies in a more eco-friendly media, such as DMC, has been investigated. The results show that the usual employed solvents (CH2Cl2, Et2O, CH3CN, etc.) can be easily replaced by DMC: not only the stereo- and regioselectivity is conserved, but also the work-up is simplified to a filtration, therefore reducing considerably the amount of solvents employed in the processes, and all the reactions are performed at room temperature, even the ones previously reported at low temperatures.
Dimethyl carbonate in the regio- and stereocontrolled opening of three-membered heterocyclic rings
Righi Giuliana;Bovicelli Paolo;
2012
Abstract
In an attempt to replace harmful or carcinogenic solvents (such as dichloromethane, acetone, etc.) with non-harmful and greener ones, the possibility of performing four already developed ring-opening methodologies in a more eco-friendly media, such as DMC, has been investigated. The results show that the usual employed solvents (CH2Cl2, Et2O, CH3CN, etc.) can be easily replaced by DMC: not only the stereo- and regioselectivity is conserved, but also the work-up is simplified to a filtration, therefore reducing considerably the amount of solvents employed in the processes, and all the reactions are performed at room temperature, even the ones previously reported at low temperatures.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.