A variety of chiral 6-hepten-1-ynes have been found to undergo cyclization to titanabicyclopentenes by (h2-propene)Ti(Oi-Pr)2 with excellent yields and degrees of exo-stereoselectivity depending on the substrate steric requirements. In the framework of a plausible cyclization mechanism several conformational features which can regulate the stereoinduction have been suggested. © 2000 Published by Elsevier Science Ltd.
Diastereoselectivity in the synthesis of bicyclic titanacyclopentenes from chiral 6-hepten-1-ynes
Francesca Cicogna;
2000
Abstract
A variety of chiral 6-hepten-1-ynes have been found to undergo cyclization to titanabicyclopentenes by (h2-propene)Ti(Oi-Pr)2 with excellent yields and degrees of exo-stereoselectivity depending on the substrate steric requirements. In the framework of a plausible cyclization mechanism several conformational features which can regulate the stereoinduction have been suggested. © 2000 Published by Elsevier Science Ltd.File in questo prodotto:
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