Pulsed Laser Deposition technique has been applied to coat titanium with hydroxyapatite based materials for orthopaedic and dental implant applications. Fe-hydroxyapatite (1 %wt of Fe) and Si-hydroxyapatite (1.4 %wt of Si) were used as coating materials since titanium itself is unable to elicit a biologically functional bone/material interface. It is known that various substitutions in the apatite lattice play a pivotal role in its biological activity, influencing solubility, surface chemistry and particle morphology. Doping hydroxyapatite with Fe enhances proliferation of osteoblast-like cells. Moreover, it creates the conditions for magnetic stimulation in situ by means of an external magnetic field, emerging as an innovative approach in the field of regenerative medicine. Whereas, Si incorporation into the hydroxyapatite lattice induces a significant increase in the osteoblast cells activity and, consequently, in bone apposition at the implant surface. These findings suggest that Si may affect the cellular response at the implant/bone interface, thereby enhancing the repair rate. The main objective of this work was to optimize the deposition parameters in order to deposit films suitable for biomedical applications, ensuring necessary structural, chemical, morphological and mechanical characteristics. Furthermore, the bioactivity of coatings was evaluated by in vitro tests in an osteoblastic/osteoclastic culture medium (?-MEM).
Nanostructured doped hydroxyapatite coatings for biomedical applications
JV Rau;A Santagata;
2014
Abstract
Pulsed Laser Deposition technique has been applied to coat titanium with hydroxyapatite based materials for orthopaedic and dental implant applications. Fe-hydroxyapatite (1 %wt of Fe) and Si-hydroxyapatite (1.4 %wt of Si) were used as coating materials since titanium itself is unable to elicit a biologically functional bone/material interface. It is known that various substitutions in the apatite lattice play a pivotal role in its biological activity, influencing solubility, surface chemistry and particle morphology. Doping hydroxyapatite with Fe enhances proliferation of osteoblast-like cells. Moreover, it creates the conditions for magnetic stimulation in situ by means of an external magnetic field, emerging as an innovative approach in the field of regenerative medicine. Whereas, Si incorporation into the hydroxyapatite lattice induces a significant increase in the osteoblast cells activity and, consequently, in bone apposition at the implant surface. These findings suggest that Si may affect the cellular response at the implant/bone interface, thereby enhancing the repair rate. The main objective of this work was to optimize the deposition parameters in order to deposit films suitable for biomedical applications, ensuring necessary structural, chemical, morphological and mechanical characteristics. Furthermore, the bioactivity of coatings was evaluated by in vitro tests in an osteoblastic/osteoclastic culture medium (?-MEM).I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
