Synthesis of b-glyco-1,2-diacylglycerols is achieved by a versatile and simple procedure based on trichloro-acetimidate methodology and use of peracetate sugar substrates. The chemical strategy was tested through stereoselective preparation of b-galacto- and b-gluco-lipid derivatives capable to trigger immune system response. The synthetic approach is designed to obtain enantiomerically pure regioand stereo-isomers including derivatives containing poly-unsaturated fatty acids.
An efficient and versatile chemical synthesis of bioactive glycoglycerolipids
Emiliano Manzo;Angelo Fontana
2012
Abstract
Synthesis of b-glyco-1,2-diacylglycerols is achieved by a versatile and simple procedure based on trichloro-acetimidate methodology and use of peracetate sugar substrates. The chemical strategy was tested through stereoselective preparation of b-galacto- and b-gluco-lipid derivatives capable to trigger immune system response. The synthetic approach is designed to obtain enantiomerically pure regioand stereo-isomers including derivatives containing poly-unsaturated fatty acids.File in questo prodotto:
Non ci sono file associati a questo prodotto.
I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
