A family of graft copolymers derivatives obtained from a,b-Poly(N-2-hydroxyethyl)-DL-aspartamide (PHEA) have been studied as potential self-assembling macromolecules forming stable polymeric micelles at low critical micellar concentration. These polymers are obtained grafting on PHEA poly(ethylene glycol) (PEG) with molar mass of 5 Kg/mol (PHEA-PEG), hexadecylamine (PHEA-C16) or both moieties (PHEA-PEG-C16). Preliminary the PHEA derivatives was characterized by a multi-angle light scattering photometer on line to a size exclusion chromatography system in obtaining the molar mass distribution of the polymers. In addition, to investigate the capacity to form micellar aggregates in aqueous medium the multi-angle light scattering photometer was used in off-line batch mode in obtaining molar mass and dimension of the polymeric aggregates.
Molecular characterization of a,b-poly[(N-hydroxyethyl)-DL-aspartamide] derivatives as potential self-assembling copolymers forming polymeric micelles
Mendichi R;Giacometti Schieroni A;
2003
Abstract
A family of graft copolymers derivatives obtained from a,b-Poly(N-2-hydroxyethyl)-DL-aspartamide (PHEA) have been studied as potential self-assembling macromolecules forming stable polymeric micelles at low critical micellar concentration. These polymers are obtained grafting on PHEA poly(ethylene glycol) (PEG) with molar mass of 5 Kg/mol (PHEA-PEG), hexadecylamine (PHEA-C16) or both moieties (PHEA-PEG-C16). Preliminary the PHEA derivatives was characterized by a multi-angle light scattering photometer on line to a size exclusion chromatography system in obtaining the molar mass distribution of the polymers. In addition, to investigate the capacity to form micellar aggregates in aqueous medium the multi-angle light scattering photometer was used in off-line batch mode in obtaining molar mass and dimension of the polymeric aggregates.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
