In an effort to design dipeptide structural mimics of protein and peptide reverse-turns, a series of 5,5-, 6,5-, and 7,5-fused 2-oxo-1-azabicycloalkane amino acids has been synthesized. A new and convenient synthetic route utilizing a Homer-Emmons reaction followed by double-bond reduction has been used to prepare the bicyclic lactams in high yields.
Synthesis of azabicycloalkane amino acid scaffolds as reverse-turn inducer dipeptide mimics
Manzoni L;
2000
Abstract
In an effort to design dipeptide structural mimics of protein and peptide reverse-turns, a series of 5,5-, 6,5-, and 7,5-fused 2-oxo-1-azabicycloalkane amino acids has been synthesized. A new and convenient synthetic route utilizing a Homer-Emmons reaction followed by double-bond reduction has been used to prepare the bicyclic lactams in high yields.File in questo prodotto:
| File | Dimensione | Formato | |
|---|---|---|---|
|
prod_187324-doc_39339.pdf
non disponibili
Descrizione: Synthesis of azabicycloalkane amino acid scaffolds as reverse-turn inducer dipeptide mimics
Dimensione
276.53 kB
Formato
Adobe PDF
|
276.53 kB | Adobe PDF | Visualizza/Apri Richiedi una copia |
I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
