alpha-Linolenic acid (ALA), eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) have been subjected to esterification with ethanol in presence of lipase B from Candida antarctica (Novozym 435®), in solvent free condition. The use of alcohol donors triethyl orthoformate (TEOF) or diethyl carbonate (DEC) instead of free ethanol, allowed working in irreversible esterification conditions and ALA-, EPAand DHA-ethyl esters were obtained in quantitative yields.
Preparation of n-3 PUFAs ethyl esters by an efficient biocatalyzed solvent-free process
R Morrone;N D'Antona;D Biondi;D Lambusta;G Nicolosi
2012
Abstract
alpha-Linolenic acid (ALA), eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) have been subjected to esterification with ethanol in presence of lipase B from Candida antarctica (Novozym 435®), in solvent free condition. The use of alcohol donors triethyl orthoformate (TEOF) or diethyl carbonate (DEC) instead of free ethanol, allowed working in irreversible esterification conditions and ALA-, EPAand DHA-ethyl esters were obtained in quantitative yields.File in questo prodotto:
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