The synthesis, photophysical properties and singlet oxygen yields of a range of polyether substituted metallo and free-base phthalocyanines are reported and discussed in the context of the potential use of these compounds as alternatives to haematoporphyrin derivatives (HpD) in the photodynamic therapy (PDT) of cancer. The tripler states of the phthalocyanines have been studied in benzene and methanol using nanosecond laser flash photolysis and pulse radiolysis. Triplet state absorption maxima occur at ca. 510 to 525 nm and the quantum yields of tripler formation (phi(T)) lie in the range 0.14 to 0.32. Triplet state lifetimes are in the range 26 to 155 mu s. Energy transfer from the tripler state (T-1) of the phthalocyanines to ground state molecular oxygen O-2 (3) Sigma(g)(-) to produce singlet oxygen O-2 (1) Delta(g) is efficient and evidence is presented for the establishment of an equilibrium in perdeuterated benzene, eqn. (a).
The Syntesis and Photophisycal Properties of Polyether Substituited Phthalocyanines of Potential Use in Photodynamic Therapy
LIUZZI R;
1997
Abstract
The synthesis, photophysical properties and singlet oxygen yields of a range of polyether substituted metallo and free-base phthalocyanines are reported and discussed in the context of the potential use of these compounds as alternatives to haematoporphyrin derivatives (HpD) in the photodynamic therapy (PDT) of cancer. The tripler states of the phthalocyanines have been studied in benzene and methanol using nanosecond laser flash photolysis and pulse radiolysis. Triplet state absorption maxima occur at ca. 510 to 525 nm and the quantum yields of tripler formation (phi(T)) lie in the range 0.14 to 0.32. Triplet state lifetimes are in the range 26 to 155 mu s. Energy transfer from the tripler state (T-1) of the phthalocyanines to ground state molecular oxygen O-2 (3) Sigma(g)(-) to produce singlet oxygen O-2 (1) Delta(g) is efficient and evidence is presented for the establishment of an equilibrium in perdeuterated benzene, eqn. (a).I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
