Continuing our research on the development of nucleopeptides as ODN analogs for biomedical and bioengineering applications, here we report the synthesis and the chemical-physical characterization of a homoadenine hexamer based on a L-diaminobutyric acid (L-DABA) backbone (dabPNA), and its binding studies with a complementary aegPNA. We demonstrated by CD and UV experiments that the L-dabPNA binds the aegPNA forming a complex with good thermal stability, that we identified as a left-handed triplex.
Evidences for complex formation between L-dabPNA and aegPNA
Pedone C;
2008
Abstract
Continuing our research on the development of nucleopeptides as ODN analogs for biomedical and bioengineering applications, here we report the synthesis and the chemical-physical characterization of a homoadenine hexamer based on a L-diaminobutyric acid (L-DABA) backbone (dabPNA), and its binding studies with a complementary aegPNA. We demonstrated by CD and UV experiments that the L-dabPNA binds the aegPNA forming a complex with good thermal stability, that we identified as a left-handed triplex.File in questo prodotto:
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