A new, mild and cheap aminolysis of 2,3-epoxy amides Ti(O-iPr)4 mediated has been developed. The reaction proceeds with excellent regioselectivity, regardless of the steric hindrance of the substituents on the heterocyclic ring, providing vicinal amino alcohols very suitable for synthetic applications.
Ti(O-iPr)4 promoted regio- and stereoselective aminolysis of 2,3-epoxy amides
Giuliana Righi;Lorenza Suber;
2012
Abstract
A new, mild and cheap aminolysis of 2,3-epoxy amides Ti(O-iPr)4 mediated has been developed. The reaction proceeds with excellent regioselectivity, regardless of the steric hindrance of the substituents on the heterocyclic ring, providing vicinal amino alcohols very suitable for synthetic applications.File in questo prodotto:
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