The interaction of the potent anti-diabetic agent bis(maltolato)oxidovanadium(IV) (BMOV) with some proteins of blood serum was studied by EPR spectroscopy, pH-potentiometry and DFT calculations. The formation of cis-VO(ma)2(hTf), cis-VO(ma)2(HSA) and cis-VO(ma)2(IgG), their role in the biotransformation in vivo and the mechanism of transport of BMOV in blood are discussed.
Biotransformation of BMOV in the presence of blood serum proteins
Sanna D;
2012
Abstract
The interaction of the potent anti-diabetic agent bis(maltolato)oxidovanadium(IV) (BMOV) with some proteins of blood serum was studied by EPR spectroscopy, pH-potentiometry and DFT calculations. The formation of cis-VO(ma)2(hTf), cis-VO(ma)2(HSA) and cis-VO(ma)2(IgG), their role in the biotransformation in vivo and the mechanism of transport of BMOV in blood are discussed.File in questo prodotto:
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