In the present paper, composite enantioselective molecularly imprinted membranes have been prepared by UV surface grafting of a commercial microfiltration polypropylene flat membranes [1]. The original membrane was modified by UV-grafting copolymerization with the functional monomer 4-vinylpyridine and the cross-linker ethylene glycol dimethacrylate (EDMA) in the presence of the (S)-naproxen as template molecule. Naproxen is an 2-aryl propionic acid derivative used in pharmaceutical industry. The (S)-isomer is about 30 times more active than the opposite (R)-isomer. The prepared MIP membranes consisted of a non selective porous support coated with a thin layer of an active polymer [2]. The enantioseparation properties have been evaluated by their capacity to resolve racemates of naproxen in aqueous phase. Investigations have been performed by means permeation experiments with a cross-flow filtration cell and the efficiency of the separation was evaluated by the evaluation of selectivity factor (???? defined as the ratio of the permeation rate of the template molecule and the opposite isomer through the MIP membrane respectively. Results showed that the (S)-naproxen imprinted membranes possess recognition properties and exhibit a selective transport of the (S)-isomer at acidic conditions. Unmodified polypropylene membranes and membranes modified without the template molecule showed equal permeation rate for both enantiomers. (1). Ulbricht, M. Belter, U. Langenhangen, F. Schneider, W. Weigel, Novel molecularly imprinted polymer (MIP) composite membranes via controlled surface and pore functionalization, Desal. 2002; 149: 293-295. (2). A. Dzgoev, K. Haupi, Enantioselective Molecularly imprinted membranes, Chirality 1999; 11: 465-469.
MOLECULARLY IMPRINTED POLYMER MEMBRANES IN ENANTIOSEPARATION
L Donato;A Figoli;E Drioli
2004
Abstract
In the present paper, composite enantioselective molecularly imprinted membranes have been prepared by UV surface grafting of a commercial microfiltration polypropylene flat membranes [1]. The original membrane was modified by UV-grafting copolymerization with the functional monomer 4-vinylpyridine and the cross-linker ethylene glycol dimethacrylate (EDMA) in the presence of the (S)-naproxen as template molecule. Naproxen is an 2-aryl propionic acid derivative used in pharmaceutical industry. The (S)-isomer is about 30 times more active than the opposite (R)-isomer. The prepared MIP membranes consisted of a non selective porous support coated with a thin layer of an active polymer [2]. The enantioseparation properties have been evaluated by their capacity to resolve racemates of naproxen in aqueous phase. Investigations have been performed by means permeation experiments with a cross-flow filtration cell and the efficiency of the separation was evaluated by the evaluation of selectivity factor (???? defined as the ratio of the permeation rate of the template molecule and the opposite isomer through the MIP membrane respectively. Results showed that the (S)-naproxen imprinted membranes possess recognition properties and exhibit a selective transport of the (S)-isomer at acidic conditions. Unmodified polypropylene membranes and membranes modified without the template molecule showed equal permeation rate for both enantiomers. (1). Ulbricht, M. Belter, U. Langenhangen, F. Schneider, W. Weigel, Novel molecularly imprinted polymer (MIP) composite membranes via controlled surface and pore functionalization, Desal. 2002; 149: 293-295. (2). A. Dzgoev, K. Haupi, Enantioselective Molecularly imprinted membranes, Chirality 1999; 11: 465-469.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
