We report a first set of peptidomimetic ligands mimicking the adhesive interface identified by recent crystallographic structures of E- and N-cadherin. Compounds 2 and 3 inhibit adhesion of Epithelial Ovarian Cancer cells with improved efficacy compared to the ADH-1 peptide, an N-cadherin antagonist that is in early clinical trials in EOC patients.
Computational design of novel peptidomimetic inhibitors of cadherin homophilic interactions
D Arosio;L Manzoni;
2015
Abstract
We report a first set of peptidomimetic ligands mimicking the adhesive interface identified by recent crystallographic structures of E- and N-cadherin. Compounds 2 and 3 inhibit adhesion of Epithelial Ovarian Cancer cells with improved efficacy compared to the ADH-1 peptide, an N-cadherin antagonist that is in early clinical trials in EOC patients.File in questo prodotto:
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Descrizione: Computational design of novel peptidomimetic inhibitors of cadherin homophilic interactions
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