Despite the role of chloride channels and anion/proton antiporters of the CLC protein family in physiological processes and different genetic diseases, their pharmacology has been under-developed. In this issue of Chemistry & Biology, Howery et al. report the synthesis of 4?-octanamidostilbene-2,2?-disulfonate, the first high-affinity inhibitor of a CLC antiporter, a critical step toward reviving the CLC pharmacology.
A Kick-Start for CLC Antiporters' Pharmacology
Zifarelli G;Pusch M
2012
Abstract
Despite the role of chloride channels and anion/proton antiporters of the CLC protein family in physiological processes and different genetic diseases, their pharmacology has been under-developed. In this issue of Chemistry & Biology, Howery et al. report the synthesis of 4?-octanamidostilbene-2,2?-disulfonate, the first high-affinity inhibitor of a CLC antiporter, a critical step toward reviving the CLC pharmacology.File in questo prodotto:
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