Whispering gallery mode resonators (WGMR), in the form of optical silica microspheres, have been recently proposed as an efficient tool for the realisation of optical biosensors. A crucial step for producing reliable biosensors is their surface functionalization. In this work we report a functionalization process based on the use of a DNA aptamer. Also the optical characterization of the functional WGMR was performed, confirming that their resonance properties are little affected by the treatments. The characterization of the immobilized aptamer layers suggests that a suitable density of bio-recognition molecules is obtained. © 2014 Springer Science+Business Media.
Aptamer based whispering gallery mode biosensor
Soria Silvia;Barucci Andrea;Berneschi Simone;Cosi Franco;Lunelli Lorenzo;
2014
Abstract
Whispering gallery mode resonators (WGMR), in the form of optical silica microspheres, have been recently proposed as an efficient tool for the realisation of optical biosensors. A crucial step for producing reliable biosensors is their surface functionalization. In this work we report a functionalization process based on the use of a DNA aptamer. Also the optical characterization of the functional WGMR was performed, confirming that their resonance properties are little affected by the treatments. The characterization of the immobilized aptamer layers suggests that a suitable density of bio-recognition molecules is obtained. © 2014 Springer Science+Business Media.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
