The combined use of Pd(OAc)(2), Cu(OAc)(2), and dioxygen in molten tetrabutylammonium acetate (TBAA) promotes an unusual cyclopropanation reaction between aryl methyl ketones and styrenes. The process is a dehydrogenative cyclizing coupling that involves a twofold C H activation at the a-position of the ketone. The substrate scope highlights the flexibility of the catalyst; a reaction mechanism is also proposed.
Palladium-Catalyzed Cross-Coupling of Styrenes with Aryl Methyl Ketones in Ionic Liquids: Direct Access to Cyclopropanes
Nacci Angelo
2014
Abstract
The combined use of Pd(OAc)(2), Cu(OAc)(2), and dioxygen in molten tetrabutylammonium acetate (TBAA) promotes an unusual cyclopropanation reaction between aryl methyl ketones and styrenes. The process is a dehydrogenative cyclizing coupling that involves a twofold C H activation at the a-position of the ketone. The substrate scope highlights the flexibility of the catalyst; a reaction mechanism is also proposed.File in questo prodotto:
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