With the achievements of the human genome project, the development of the innovative DNA-microarray technology is bringing new understanding of the genetic basis of common diseases. In the last years, microarray technology has rapidly improved transitioning from basic research applications into detection and diagnostic formats. For instance, the most successful application of these genomic assays has been in the subtypization of human cancers, including the ability to predict clinical outcomes. In this chapter, we will outline the basic principles of this technology and provide some real examples of how its use in clinical practice has an enormous potential in rationalizing clinical management, and in advancing strategies for disease prevention and public healthcare. © 2012 by Nova Science Publishers, Inc. All rights reserved.
DNA microarray in a clinical setting
Paratore S;Cavallaro S
2011
Abstract
With the achievements of the human genome project, the development of the innovative DNA-microarray technology is bringing new understanding of the genetic basis of common diseases. In the last years, microarray technology has rapidly improved transitioning from basic research applications into detection and diagnostic formats. For instance, the most successful application of these genomic assays has been in the subtypization of human cancers, including the ability to predict clinical outcomes. In this chapter, we will outline the basic principles of this technology and provide some real examples of how its use in clinical practice has an enormous potential in rationalizing clinical management, and in advancing strategies for disease prevention and public healthcare. © 2012 by Nova Science Publishers, Inc. All rights reserved.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
