The structural organization of both prokaryotic and eukaryotic chromosomes has evolved following a common principle: the need for storing the genetic information in topologically independent domains consisting of one or more genes and of all the elements required in cis for their functioning. The elements that belong to the same functional unit are topologically linked: they depend on each other and cooperate.
Purification and use of DNA minicircles with different linking numbers.
Caserta M;Di Mauro E
1999
Abstract
The structural organization of both prokaryotic and eukaryotic chromosomes has evolved following a common principle: the need for storing the genetic information in topologically independent domains consisting of one or more genes and of all the elements required in cis for their functioning. The elements that belong to the same functional unit are topologically linked: they depend on each other and cooperate.File in questo prodotto:
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