We have analyzed the localization and the dependence upon superhelical density of the DNA sites which modify their conformation under torsional strain in a mouse Ig L.kappa. gene. The conformational variations occur on DNA sites which have been defined as protein interaction sites and consensus sequence motifs: the 5'-upstream regulatory decanucleotides, the TATA sequence, the consensus heptanucleotides of the J recombinational sequences.
DNA CONFORMATIONAL VARIATIONS IN THE IN-VITRO TORSIONALLY STRAINED IG KAPPA LIGHT CHAIN GENE LOCALIZE ON CONSENSUS SEQUENCES
CASERTA M;DI MAURO E;CAMILLONI G
1988
Abstract
We have analyzed the localization and the dependence upon superhelical density of the DNA sites which modify their conformation under torsional strain in a mouse Ig L.kappa. gene. The conformational variations occur on DNA sites which have been defined as protein interaction sites and consensus sequence motifs: the 5'-upstream regulatory decanucleotides, the TATA sequence, the consensus heptanucleotides of the J recombinational sequences.File in questo prodotto:
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