Molecularly imprinted membranes (MIMs) represent a special format of molecularly imprinted polymers which have bio-mimetic molecular recognition properties. In fact, Owing to the presence of specific recognition sites in its matrix, an imprinted membrane is able to recognize and separate a molecule of particular interest (called "template" or "target analyte") from a mixture of similar chemical compounds. The molecular recognition is achieved thanks to the chemical and spatial complementary existing between the template and the recognition sites of the membrane. Combining the advantages of both, the imprinting technique and the oldest membrane technology, MIMs signed a new pathway for the detection, transport or retention of targeted chemical and biological compounds. As example, MIMs were produced for molecular discrimination of drugs [1], in chiral separation, for the recognition of organic pollutants [3] and much other. Aim of this work was the development of molecularly imprinted membranes with specific recognition properties for the organophosphorus pesticide dimethoate (DMT) and the primary primary amine 4,4'-methylendianiline (MDA). Membranes were prepared via the phase inversion inversion technique (see Fig. 1) using polyacrylonitrile and its copolymers with different functional co-monomers (acrylic acid, methacrylic acid, itaconic acid and acrylamide) ad hoc synthesized by the water-phase precipitation polymerization process. Fig.1. Schematic representation of the membrane preparation process. The recognition properties of the prepared membranes were evaluated by rebinding tests performed in a dead-end filtration cell using aqueous or organic solutions of DMT and MDA, respectively. Results showed that all the imprinted membranes exhibit specific binding for the templates and could be used in solid-phase extraction processes such as removal of genotoxins from organic solvents and pesticides from water samples. [1] F. Trotta, C. Baggiani, M.P. Luda, E. Drioli, T. Massari, J. Membr. Sci., 2007, 254, 13-19. [2] L. Donato, A. Figoli, E. Drioli, J. Pharm. Biomed. An., 2005, 37, 1003-1008. [3] V. Kochkodan, N. Hilal, V. Melnik, O. Kochkodan, O. Vasilenko, Adv. Colloid Interface Sci., 2010, 159, 180-188.
Development of molecularly imprinted membranes for selective recognition of toxic compounds, XXV Congresso Nazionale della Società Chimica Italiana, Arcavacata di Rende, 7-12 Settembre 2014
2014
Abstract
Molecularly imprinted membranes (MIMs) represent a special format of molecularly imprinted polymers which have bio-mimetic molecular recognition properties. In fact, Owing to the presence of specific recognition sites in its matrix, an imprinted membrane is able to recognize and separate a molecule of particular interest (called "template" or "target analyte") from a mixture of similar chemical compounds. The molecular recognition is achieved thanks to the chemical and spatial complementary existing between the template and the recognition sites of the membrane. Combining the advantages of both, the imprinting technique and the oldest membrane technology, MIMs signed a new pathway for the detection, transport or retention of targeted chemical and biological compounds. As example, MIMs were produced for molecular discrimination of drugs [1], in chiral separation, for the recognition of organic pollutants [3] and much other. Aim of this work was the development of molecularly imprinted membranes with specific recognition properties for the organophosphorus pesticide dimethoate (DMT) and the primary primary amine 4,4'-methylendianiline (MDA). Membranes were prepared via the phase inversion inversion technique (see Fig. 1) using polyacrylonitrile and its copolymers with different functional co-monomers (acrylic acid, methacrylic acid, itaconic acid and acrylamide) ad hoc synthesized by the water-phase precipitation polymerization process. Fig.1. Schematic representation of the membrane preparation process. The recognition properties of the prepared membranes were evaluated by rebinding tests performed in a dead-end filtration cell using aqueous or organic solutions of DMT and MDA, respectively. Results showed that all the imprinted membranes exhibit specific binding for the templates and could be used in solid-phase extraction processes such as removal of genotoxins from organic solvents and pesticides from water samples. [1] F. Trotta, C. Baggiani, M.P. Luda, E. Drioli, T. Massari, J. Membr. Sci., 2007, 254, 13-19. [2] L. Donato, A. Figoli, E. Drioli, J. Pharm. Biomed. An., 2005, 37, 1003-1008. [3] V. Kochkodan, N. Hilal, V. Melnik, O. Kochkodan, O. Vasilenko, Adv. Colloid Interface Sci., 2010, 159, 180-188.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
