Neuronal apoptosisapoptosis represents an intrinsic suicide program, by which a neuronneuron orchestrates its own destruction. Although engagement of apoptosis requires transcriptiontranscription and protein synthesisprotein synthesis , the complete spectrum of genesgenes involved in distinct temporal domains remained unknown until the advent of genomicsgenomics . In the last 10 years, the genome sequences and the developmentdevelopment of high-throughput genomic technologiesgenomic technologies , such as DNA microarraysDNA microarrays , have offered the unprecedented experimental opportunities to explore the transcriptional mechanisms underlying apoptosis from a new systems-level perspective. This review goes over this genomic approach and illustrates the use of microarraymicroarray methodology to dissecting the multigenic program underlying neuronal apoptosis.
Genomic analysis of transcriptional changes underlying neuronal apoptosis.
Cavallaro;Sebastiano
2015
Abstract
Neuronal apoptosisapoptosis represents an intrinsic suicide program, by which a neuronneuron orchestrates its own destruction. Although engagement of apoptosis requires transcriptiontranscription and protein synthesisprotein synthesis , the complete spectrum of genesgenes involved in distinct temporal domains remained unknown until the advent of genomicsgenomics . In the last 10 years, the genome sequences and the developmentdevelopment of high-throughput genomic technologiesgenomic technologies , such as DNA microarraysDNA microarrays , have offered the unprecedented experimental opportunities to explore the transcriptional mechanisms underlying apoptosis from a new systems-level perspective. This review goes over this genomic approach and illustrates the use of microarraymicroarray methodology to dissecting the multigenic program underlying neuronal apoptosis.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
