Reporting in this issue of Developmental Cell, L'honoré et al. (2014) show that a network composed of Pitx2/Pitx3 and downstream antioxidant enzymes protects differentiating skeletal muscle from excessive reactive oxygen species production during fetal myogenesis. Genetic deficiency of Pitx2/Pitx3 results in irreversible oxidative DNA damage and apoptosis, impairing skeletal muscle development.
Redox or Death: Checking on Fetal Myogenesis
Latella LuciaPrimo
;
2014
Abstract
Reporting in this issue of Developmental Cell, L'honoré et al. (2014) show that a network composed of Pitx2/Pitx3 and downstream antioxidant enzymes protects differentiating skeletal muscle from excessive reactive oxygen species production during fetal myogenesis. Genetic deficiency of Pitx2/Pitx3 results in irreversible oxidative DNA damage and apoptosis, impairing skeletal muscle development.File in questo prodotto:
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Descrizione: Redox or death: checking on fetal myogenesis
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